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A study conducted by librarians of Emory University in 2022 found that Cureus and Oncotarget together represented 50% of publications deemed controversial or predatory.

Cureus was also criticized for having published a revision of an article that had been elsewhere retracted because of methodological reasons and scrutiny for “possible violations of medical ethics and human rights” (the results of a Covid-19 proxalutamide trial in Brazil).[9]

In April 2022, Cureus displayed a Wall of Shame to "highlight authors who have committed egregious ethical violations as well as the institutions that enabled them".[10] This feature drew criticism as it unjustly put the emphasis on individuals, in particular the corresponding author. This feature was withdrawn in May 2023.

In April 2022, Cureus published notes of concerns relating to nearly 50 papers published without the knowledge of the corresponding author/disputed authorship. In January 2024, 56 papers were retracted.[11]

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