I would strongly suggest you stay away from Big 4. Personally I don't think it is worth the sacrifice.
2) If you were a woman who love to stay fit and pretty, I also suggest you stay away from Big 4. Aging is accelerated there:)
3) If you were a father and never mind how you look like, go for it, and make good money for your family. Just resist the temptations out there when you do not spend quality time with your spouse.