The wholesale acquisition cost (WAC) for sofosbuvir is $1,000 per 400 mg pill. Accordingly, the cost for the sofosbuvir component in a 12-week treatment course is $84,000 (and the total regimen cost is depends on the other medications used in combination with sofosbuvir).In general, the generic preparations are less expensive than the brand drugs. As a rough estimate, a 12-week course of generic ribavirin is in the range of $550 to $850. Accordingly, the ribavirin component of a 48-week treatment course costs approximately $1100 to $1700.