本文发表在 rolia.net 枫下论坛Annals of Pharmacology and PharmaceuticsRemedy Publications LLC. 2021 | Volume 6 | Issue 1 | Article 11991IntroductionCoronavirus Disease 2019 (COVID-19) is caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and has become a serious health issue since its emergence in late 2019 [1,2]. The outbreak of this disease originated in Wuhan, Hubei Province, China, before spreading rapidly throughout the world [2]. The COVID-19 pandemic was declared an international emergency in 2020 [3]. As of May 2021, global death toll due to COVID-19 is estimated to be approximately 3.3 million [4]. SARS-CoV-2 is an enveloped virus and has a single-stranded negative-sense RNA genome of 29.9 kilobases [5]. The virus attaches to the host cell surface of type I and II pneumocytes, endothelial cells and ciliated bronchial epithelial cells [6]. Although several vaccines against the disease have already been developed and administered [7], the pandemic has not yet ended. Furthermore, currently variant types of SARS-CoV-2 virus have been reported from England (B.1.1.7 variant) and South Africa (variant B.1.351) that appear to be spread more readily than the original virus [8]. Both of these variants carry a common mutation (N501Y) in the Receptor-Binding Domain (RBD) of the spike protein (S protein) [5]. This mutation is important in binding of the spike protein to human cell surface receptor, Angiotensin-Converting Enzyme 2 (ACE2), a type I transmembrane glycoprotein with carboxypeptidase activity [5].To control the spread of COVID-19, it is essential to develop and deploy safe but effective disinfectants against the virus alongside novel antiviral drugs and vaccines [8]. While ethanol is known to be effective against the virus [9], it cannot eradicate the virus present in the air. Chlorine Dioxide (ClO2) (CD) is a water-soluble yellow gas at room temperature and is a stable free radical [10]. CD can be used as a gas or an aqueous solution to inactivate both viruses and bacteria [11-15]. The powerful disinfection action of CD against microbes is due to its strong oxidizing activity against proteins [16]. Moreover, safe and permissible concentrations of CD have been well documentedInhibition of the Binding of Variants of SARS-CoV-2 Coronavirus Spike Protein to a Human Receptor by Chlorine Dioxide更多精彩文章及讨论，请光临枫下论坛 rolia.net